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Hope Rises For Cancer Patients As Drug Passes First Test

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People with untreatable cancers now have hope if a new drug that will help their immune   attack their own tumours passes final test.
The drug according to reports is still at experimental stage and involves only 16 patients.
The new cancer breakthrough but has been called a “leap forward” and a “powerful” demonstration of the potential of such technology.
Each person had a treatment developed just for them, which targeted the specific weak spots in their tumour.
Reports says it’s too early to fully assess the therapy’s effectiveness and it is expensive and time-consuming.
The work focuses on a part of the immune system called T-cells, which patrol the body and inspect other cells for problems.
The drug uses proteins – called receptors – to effectively sniff out signs of infection or deviant cells that have become cancerous.
Cancers can be tricky for T-cells to spot. A virus is distinctly different to the human body, but cancers are more subtle because they are a corrupted version of our own cells.
The idea of the therapy is to boost levels of these cancer-spotting T-cells. It has to be tailored to each patient as each tumour is unique.
The researchers scoured patient’s blood for rare T-cells that already had receptors which could sniff out their cancer and after then harvested other T-cells that could not find the cancer and redesigned them.
Original receptors, which may find other problems or infections, were replaced with those from the cancer-searching T-cell.
With efficacy the drug help modified T-cells  then put back into the patient to seek out the tumour
Transforming T-cells into a form that can hunt cancer requires considerable genetic manipulation to both remove the genetic instructions for building their old receptors, and give them the instructions for the new ones.
The drug was made possible by tremendous advances in the gene-editing technology Crispr, which acts like a pair of molecular scissors – allowing scientists to easily manipulate DNA. The researchers who developed Crispr won which the Nobel Prize for Chemistry in 2020.

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WHO Begins Regulation On Antibiotic Waste

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The World Health Organisation (WHO) has begun acting to curb effects of antibiotic pollution.
The new guidance on wastewater and solid waste management for antibiotic manufacturing sheds light on this important but neglected challenge ahead of the United Nations General Assembly (UNGA) High-Level Meeting on antimicrobial resistance (AMR) taking place on 26 September 2024.
The emergence and spread of AMR caused by antibiotic pollution could undermine the effectiveness of antibiotics globally, including the medicines produced at the manufacturing sites responsible for the pollution.
Despite high antibiotic pollution levels being widely documented, the issue is largely unregulated and quality assurance criteria typically do not address environmental emissions. In addition, once distributed, there is a lack of information provided to consumers on how to dispose of antibiotics when they are not used, for example, when they expire or when a course is finished but there is still antibiotic left over.
“Pharmaceutical waste from antibiotic manufacturing can facilitate the emergence of new drug-resistant bacteria, which can spread globally and threaten our health. Controlling pollution from antibiotic production contributes to keeping these life-saving medicines effective for everyone,” said Dr Yukiko Nakatani, WHO Assistant Director-General for AMR ad interim.
Globally, there is a lack of accessible information on the environmental damage caused by manufacturing of medicines.

 

“The guidance provides an independent and impartial scientific basis for regulators, procurers, inspectors, and industry themselves to include robust antibiotic pollution control in their standards,” said Dr Maria Neira, Director, Department of Environment, Climate Change and Health, WHO. “Critically, the strong focus on transparency will equip buyers, investors and the general public to make decisions that account for manufacturers’ efforts to control antibiotic pollution.”

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Kebbi Harmonises Doctors’ Salaries To Curb Brain Drain

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In a concerted effort to curb brain drain, the Kebbi State Government has harmonised medical doctors’ salaries to be at par with their colleagues in the federal government’s tertiary health facilities.
Kebbi State Commissioner for Health, Musa Inusa-Isma’il, disclosed this at the handing over of ambulances to the state-owned health facilities at the Ministry of Health in Birnin Kebbi yesterday.
Inusa Isma’il, according to a statement by Ahmed Idris, the Chief Press Secretary to the governor, said the essence of the harmonisation was to retain the existing medical doctors and attract more to the services of the state.
According to him, the doctors across the state had already started enjoying the new salaries from August 2024.
He said the release of the vehicles was in fulfilment of Governor Nasir Idris’ promise to uplift health care services in the state.
“His Excellency said I should inform you, the beneficiaries of this gesture, that the vehicle should be strictly used for the intended purpose. It should not be used for anything else.
“If there is no referral case, each of the vehicles must be parked at the hospital by 6 pm. The governor said you should warn your drivers against reckless driving as well as violating the instructions.
“We should also do everything possible to reciprocate the gesture by working according to the terms and conditions attached,” he advised.
The benefiting health facilities included Sir Yahaya Memorial Hospital, Birnin Kebbi; State Teaching Hospital, Kalgo; General Hospital, Argungu; General Hospital, Yauri; General Hospital, Zuru; and General Hospital, Bunza.

 

 

In his speech, the permanent secretary of the ministry, Dr Shehu Koko, recalled that the ambulances were handed over to the ministry last Friday by the governor for the onward handover to the benefiting hospitals.
He observed that the ambulances would go a long way in improving the referral system in the state, adding that delays in reaching the secondary and tertiary facilities would be eliminated.
The permanent secretary attributed the high rate of maternal mortality in the country to delays in getting to the health facilities for proper medical care.
“We believe with the provision of these ambulances, part of the gaps we have in our referral system will be addressed, whereby patients who require secondary healthcare could be easily transported to secondary and tertiary health centres, where they can get such help,” he said.
In a goodwill message, Commissioner for Information and Culture Alhaji Yakubu Ahmed expressed gratitude to the governor for the support he has given to the ministry to excel.
While advising the beneficiaries to use the vehicles judiciously, the commissioner advised that services and maintenance of the vehicles must be prompt to derive the maximum benefits from the vehicles.
The commissioner also highlighted some achievements recorded by the government in the last year, including beautification of the state capital, completion of a multimillion-naira ultramodern state secretariat, road construction, construction and renovation of classrooms and upgrading of some health facilities, among others.

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Oyo, Osun Customs Seizes N713m Worth Drugs, Contraband 

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Nigeria Customs Service (NCS), Oyo/Osun Area Command says it intercepted 2,448 wraps of cannabis sativa and 2,667 used tyres in two and half months.
The Area Controller, NCS, Dr. Ben Oramalugo, disclosed this in Ibadan while briefing newsmen on the Command’s achievements between June 14 and August 29. 2024.
Oramalugo said other seized items include a used Mazda car, 2,183 bags of 50 Kilogrammes of foreign rice, 753 kegs and 94 drums of petrol, as well as 24 bales of used clothing.
The Area Commander said the total Duty Paid Value (DPV) of the seizures in the months under review stood at N713,150,400.
He expressed regret that the continuous consumption of hard drugs by some youths was not helping the fight against insecurity in the nation.
This, he said, must not be allowed to continue for the future of the country.
According to him, NCS has a responsibility to support the National Drug Law Enforcement Agency (NDLEA) in minimising or eradicating the drug menace contributing to national insecurity.
“Drugs are very dangerous and no human being will kill or rob without being under the influence of drugs.
“The Command will, however, not allow the business of drugs to thrive in our areas of jurisdiction.
“This is why we have robust collaboration with NDLEA, and we hope there will be proper prosecution when the seized drugs are handed over to NDLEA”, he stated.
He continued that the Command intensified its efforts at combating smuggling activities and achieved successes despite operating in difficult terrains and with less-advanced technology
Oramalugo further said the Command is adopting technological innovations and strategies, collaborating with other security agencies, all in a bid to tackle the ever-evolving tactics of smugglers.
The Commander said the Command generated N48.7 billion as revenue between January and August 2024, representing a 2.74 per cent increase compared to the N47.4bn generated within the same period in 2023.
“These seizures represent a significant blow to smugglers and a win for lawful trade and economic stability.
“The milestones recorded here are as a result of strategic intelligence gathering, increased patrols and dedication of the command officers who demonstrated exceptional vigilance and commitment to duty”, Oramalugo said.
The controller said the proactive measures taken by the various anti-smuggling teams had not only prevented illegitimate trade but also prevented communities from dangers posed by illicit goods.
He said the Command remained committed to upholding the highest standards of professionalism and integrity in its operations.
He commended the NCS Comptroller General, Bashir Adeniyi, and his management team for supporting the command to achieve its core mandate.
Oramalugo commended Gov. Seyi Makinde of Oyo State, other sister security agencies and stakeholders for supporting the command.
12 officers were issued letters of commendation for their contributions to the achievements recorded within months under review.
The seized drugs were handed over to NDLEA representative,  Wokoma Terry, who appreciated the customs for the seizures.

Chinedu Wosu

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