Social/Kiddies
How Brain Inflammation May Aid Autism
Autism, a disease of serious developmental disorder that impairs the ability of a person to communicate and interact, may be caused by inflammation of the brains of young people, according to research published in Science Translational Medicine recently.
Prior to the origins of many neurodevelopment disorders, which remain uncertain, the new study of post-modern brain tissue from children who died between the ages of one and five has shown how inflammation affects the brain.
For the first time, researchers from the University of Maryland School of Medicine (UMSOM) discovered that inflammation alters the development of vulnerable brain cells and this could have mechanistic links to neurodevelopmental disorders and could lead to treatments for many different childhood – on set neurodevelopmental disorders.
The UMSOM’s Institute for Genome Sciences (IGS), Department of Pharmacology and the University of Maryland Medicine Institute of Neuroscience Discovery (UM – MIND) conducted the research. The study is part of a collection of nearly 30 papers describing the development and diversity of cell types in the human brain.
Though previous research had shown that babies born with abnormalities of the cerebellum frequently go on to experience neurodevelopmental disorders, the new study specifically looked at the cerebellum because it is one of the first brain regions to begin developing and one of the last to reach its maturity, but remained understudied.
The lead author of the research team, IGS Scientist and Associate Professor in the Department of Psychiatry at UMSOM, Seth Ament, Ph.D, stated that, “with the fairly new technology of single nucleus RNA sequencing, we could look at the cell level and see changes in the brain”. Also, the Co – Leader of the research team, the James and Carolyn Frenkil Dean’s Professor and Chair in Pharmacology and Director of UM – MIND, Margaret McCarthy, Ph.D,added, “This has never been done before in this age group and in the context of inflammation. The gene expression in the cerebella of children and inflammation were remarkably consistent”.
From the report, the researchers examined donated post mortem brain tissues of 17 children who died when they were one to five years old, eight from conditions that involved inflammation and nine from accidents.
None of the donors had been diagnosed with a neurological disorder prior to death. The two groups were similar in age, gender, race/ethnicity and time since death. These unique brain tissue specimens had been collected over many years by UMSOM researchers at the University of Maryland Brain and Tissue Bank.
According to the study, two specific, yet rare types of cerebellar neurons were most vulnerable to brain inflammation – the Golgi and Purkinje neutrons. At the single cell level, these two types of neurons showed premature disruption of their maturation.
Dr Ament said, “although rare, Purkinje and Golgi neutrons have critical functions. During development, Purkinje neurons form synapses connecting the cerebellum to other brain regions involved in cognition or emotional control, while Golgi neurons coordinate communication between cells within the cerebellum. Disruption of either of these developmental processes could explain how inflammation contributes to conditions like autism spectrum disorders and schizophrenia”.
Also, the UMSOM Dean, who is also Executive Vice President for Medical Affairs, UM Baltimore, Dr. Mark Gladwin said, “this study is one of the first to show that gene expression challenges during inflammation which may set the stage for later cellular dysfunction,such as reducing synaptic connectivity or altering energy metalbolism.
“It is critical to understand these mechanisms and changes at the cellular level during brain development in the hope that someday we can develop treatments for neurodevelopmental disorders “, stated a distinguished professor at UMSOM, Akiko Bowers.
However, more studies indicate that the rate of autism is rising. A growing area of research focuses on interaction of genetic and environmental factors. It is likely that a woman’s exposure to harmful contaminants during pregnancy may trigger a genetic mutation leading to autism in her child. No link has been found between autism and vaccines, including those containing thimerosal, a mercury based compound.
Other environmental factors that may be associated with autism include advanced parental age as at time of conception, pre natal exposure to air pollution or certain pesticides, maternal obesity, diabetes or immune system disorders, extreme prematurity or very low birth weight and any birth difficulty leading to periods of oxygen deprivation to the baby’s brain.
People with autism have trouble with communication . They have trouble understanding what other people think and feel. This makes it hard for them to express things, either with words or through gestures, facial expressions and touch.
People with autism may have problems with learning. Their skills might develop unevenly. They could have trouble communicating but be unusually good at art, music, mathematics or things that involve memory. Because of this, they might do especially well on tests of analysis or problem solving.
More children are diagnosed with autism now than ever. But the latest numbers could be higher because of changes in how its diagnosed, not because more children have the disorder.
According to Key Autism Statistics, as of 2023, in the US, around 1 in 36 children has been diagnosed with autism. Around 75 million people have autism spectrum disorder, that is 1 percent of the world’s population. 1 in 100 children are diagnosed with autism as of 2021. Autism prevalence has increased 178 percent since 2020. The country with the highest rate of diagnosed autism in the world is Qatar and the country with the lowest rate is France . Also, around 4 times as many boys have autism as girls.
By: Ibinabo Ogolo
It is the idea of God that family should exit. Children form part of the family. God loves family so much that Jesus was born into the family of Joseph.
Everyone’s family is good and important. Children should not look down on their family whether they are rich or poor.
Children should respect and honour their family and foster love among their siblings. They should work together and make peace in the family. They should always stand in the gap. It is good for family members to carry all along since everyone may not be doing well.
The Christianity that children learn is practised in family. Faith-based organisations do a great job in moulding children’s character. Those are the behaviours that children exhibit towards siblings in family.
Every child born in a family is there for a purpose. A baby born into a family is supplying something. It may be joy, wealth and so on. Everyone is important in a family.
Adolescents who have graduated from school but may not be contributing financially can do one or two things at home. You can engage in preparing meals at home while parents are away for a job or business. Contributing in house chores will go a long way to relieve parents of stress after a day’s job.
What do you contribute to your family, especially during holidays both in nuclear and extended family?
The family you were born is constant but friends are temporary. You can decide not to continue in friendship but you cannot cut off your family. No matter how bad you think your family is and you decide to leave home, you must surely return. Your friends can harbour you for a while.
The child’s first identity comes from the family. What the child learns first comes from the family.
Family is the centre of love and care. People have started playing down on marriage because of neglect on basics of family. Marriage starts today and and the next few months, it is threatened. Respect for family plays a crucial role in marriage.
No child grows without parental control and influence. If a child refuses to grow without taking instructions from parents, he may grow up being wild. There are consequences when children do not obey their parents. There are those who want to be rebellious against their parents. They should know that their length of days are tied to their parents.
Your bioligical parents know you more than every other person. There is the wisdom and knowledge your parents have that you do not so it is proper to listen to them before choosing carriers both in academics and job. A young man or woman can choose who to get married to, but a greater role in the choice of who to marry and the marriage proper comes from the parents.
They know what is best for you. No matter how modern trends will influence you and prove it wrong, parent is the key. No one can love you more than your parents because they are your blood.
A lot of parents have been traumatised due to the fact that children they nurtured and trained turned their back on them at older age. Children should not abandon their parents for any reason.
As you grow up, situations may arise in marriage when you decide it is over with your spouse, but no matter the level of provocation with your parents, they will not despise you. Parents will also play a role in that regard. Problem arises in every family but how it is handled matters a lot.
Some children honour their mentors more than their parents. Although there are parents who shy away from their responsibilities. It is important that parents take full responsibility of their children. You cannot bring a child to the planet earth and refuse to perform roles as a parent. But parents may not quantify what they spent from childhood to adolescence. That is a blessing children cannot get from another person.
There are people who have attributed their failure in life to the fact that their parents, especially mothers are witchcraft. It is wrong to feel that your mother is instrumental to your failure in life. The only way to success is hardwork.
Let money not determine the level of love for your parents. Wherever a child goes, family is constant.
Eunice Choko-Kayode
Naturally, when a child is born, it is the role of the father and mother to decide a suitable name for the child. The husband and wife normally discuss and suggest the English or vernacular name of the baby.
But sometimes, when a baby comes into a family, grandparents hearts are usually filled with joy to the extent that they want to answer present, by giving their own names not minding the fact that the biological parents have given theirs.
This happens mostly when the marriage is an inter-tribal one. It also happens even in intra-tribal marriage. Grandparents want equal representation as far as naming a child is concerned. They also have special names as a result of circumstances surrounding the birth of the child.
This is still happening till date.
A lot of people have viewed this in different ways but there is nothing wrong about it. The most important thing is that the child bears as many names as he or she can. But one thing is certain, the child must bear one name in school.
Should circumstance determine a child’s name?
Women who are more emotional are always eager to name their children considering the circumstances surrounding the child’s conception and arrival.
The issue of grandparents naming a child comes up mostly when it is the first of the family.
In naming children by some parents in the olden days, they named their children according to the days in the week in which they were born, like Sunday, Monday, Friday and so on.
You may be shocked to hear that whether a child is given 10 names by parents or grandparents, when he or she grows up, will decide to change. There are several cases where some persons decided to change especially when they feel that the names given by their parents and grandparents do not give them joy. If they are not doing well in life, they may claim that their misfortune is caused by the name their parents.
Competition among children in schools be it primary, (kindergarten) and secondary come in different forms. It can be Mathematics , debate, quiz, spelling bee,competition, from organisations like Cowbell, multi-national companies, faith-based organisations among others.
They are organised mostly for selected intelligent ones, the best among their peers to represent a class, school or group. Prizes are normally set aside for the best as well as consolation prizes for runners-up at the end of each session.
The question is, are children willing to accept defeat when they fail? As parents, guardians, can you encourage your children or wards to accept defeat instead of shouting and comparing them with others who may be performing better either in schools or outside.
Some parents may be blaming their children for not doing well in competitions. They will like to tell their children if others who may perform better have ten heads. Those group of parents blame their children for every failure.
For your children to do better in competition, the parents too must have emotional intelligence. When you continue to blame your children for failure, how intelligent are you?
Some parents always want their children to be in the 1st position and unhappy whenever they secure 2nd position. There were instances where children smashed their trophies because they never got the position they wanted to get and their parents supported them.
Children should be able to accept it whether they win or not. They should be encouraged for every performance. Discourage the issue of “shame, shame, shame, shame”.
A parent says she always tells her children to win even if they will fail. Always give them the mentality that they can win. Children should be given the impression that they can win prizes and laurels in every competition.
Parents should not isolate their children from others in the neighbourhood. Allow them to play with others. Don’t threaten your children that you may not pay their schools fees if they fail. Comparing them with others may encourage or discourage them.
Coming first or getting award as a first class student from the university sometimes does not mean that the person is the best. And if the child does not merit any award in the lower classes, does not mean that he can not merit first class also.
It should be noted that coming first in academic competition may not really mean that the competitor will be the best at work place or business.
Accepting defeat is a way to move higher. Even if a child who competed with others did not come first, there are consolation prizes for runners-up. When you advise the child to accept defeat, you are encouraging her to win in next competition.
Remember all children cannot be on the same knowledge level Their learning abilities defer.
Eunice Choko-Kayode